In 1995, global production of maleic anhydride was estimated at. Special hazards arising from the substance or mixture. Common name maleic anhydride synonyms 2,5furandione formula c 4 h 2 o 3 cas number 108316 component cas number concentration maleic anhydride 108316. Maleic anhydride is the classic dielsalder reagent. Complete substitution of chymotrypsinogen was achieved under mild conditions and the extent of reaction could be readily determined from the spectrum of the maleylprotein. Maleic anhydride was shown to react rapidly and specifically with amino groups of proteins and peptides. It is a cyclic dicarboxylic anhydride and a member of furans.
Maleic anhydride msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. Solid maleic anhydride can be supplied upon request. The maleic anhydride mah grafted polyolefins in the amplify gr series offer. Adhesion to metal, polyethylene terephthalate pet, polycarbonate, glass, foil, cellulose, and polyolefins good heat resistance impact resistance in nylon blends inorganic filler compatibilization for. Manufacturing processes for maleic anhydride are described, including those using fixed fluidized and transportbed technologies for selective oxidation of butane.
The use of maleic anhydride for the reversible blocking of. Sigmaaldrich 3050 spruce street saint louis mo 63103 usa telephone. Enter synonyms, trade names or additional information found in section 1. Therefore, on leaking of the product onto iron apparatus and hot piplines heating, the place must be thoroughly cleaned with water. This is the page for msds information on the maleic anhydride grafted polymers from optimized grafts. Prior to the dehydration stage, about 1535 parts by weight of maleic. Liquid maleic anhydride is supplied in tank trucks or containers.
Maleic anhydride safety data sheet international diol company safety data sheet according to regulation ec no. Groups of 10 male and 20 female rats were given maleic anhydride in corn oil by gavage at 0, 20, 55, or 150 mgkgday until sacrifice. In case of more serious fires, also alcoholresistant foam and water spray. Specifically, when maleic anhydride is converted to maleic andor fumaric acid, it is a great preservative or flavor enhancer. Maleic anhydride 95 100% 108316 get medical attention immediately.
Maleic anhydride is thus widely used as a starting material for the production of adhesives, surfactants, insecticides, herbicides, fungicides, and as a crosslinking component for many applications. Tccs maleic anhydride is a highly reactive chemical intermediate with present and potential uses in practically every field of industrial chemistry. Maleic anhydride series products are essential to the production of a multitude of resins and plastics, agricultural and industrial chemicals, petroleum additives, paper sizing, water treatment chemicals, epoxy curing agents, artificial sweeteners. Longterm health effects prolonged vapor contact to maleic anhydride may cause conjunctivitis and photophobia sensitivity of. Chemical properties of maleic acid cas 110167 download as pdf file download as excel file download as 2d mole file predict properties. Production of maleic anhydride background maleic anhydride is a versatile chemical intermediate used to make unsaturated polyester resins, lube oil additives, alkyd resins, and a variety of other products. India veritas house, 70 mint road, fort, mumbai 400 001. Maleic anhydride is a highly reactive chemical intermediate with present and potential uses in practically every field of industrial chemistry. Safety data sheet northwest missouri state university. D3366 test method for color of maleic anhydride and phthalic anhydride in the molten state and after heating platinumcobalt scale. Exposure to maleic anhydride can cause headache, dizziness, nausea and vomiting. Maleic anhydride manufacture from nbutane fixedbed technology maleic anhydride man is a multifunctional chemical intermediate with applications in several fields of the chemical process industries cpi. Material safety data sheet maleic anhydride section 1 chemical product and company identification msds name.
Material safety data sheet maleic anhydride msds section 1. It was used for work in 1928, on the reaction between maleic anhydride and 1,3butadiene, for which otto paul hermann diels and kurt alder were awarded the nobel prize in 1950. Files are available under licenses specified on their description page. A combination of these processes should be important. Maleic anhydride is a colorless to white solid that forms orthorhombic crystals and decomposes in water. Chemical product and company identification product name. It is through this reaction that maleic anhydride converted to many pesticides and pharmaceuticals. The anhydride of maleic acid has five atoms in its cyclic molecule, the unsaturated bond undergoes free radical polymerization in the presence of an initiator. Sodium ions and pyridine are particularly effective, even at concentrations below 0. Maleic anhydride causes severe burns and may produce an allergic skin reaction in sensitive individuals.
Maleic anhydride manufacture technology free library. Astm d3504 96 standard specification for maleic anhydride. In case of inhalation of decomposition products in a fire, symptoms may be delayed. Referenced documents purchase separately the documents listed below are referenced within the subject standard but are not provided as part of the standard astm standards. Use a fire fighting agent suitable for flammable liquids such as dry chemical or carbon dioxide to extinguish. It is through this reaction that maleic anhydride is used in many pesticides and pharmaceuticals. Other companies are charging thousands of dollars to. View or download the maleic anhydride msds material safety data sheet or sds for 800408 from milliporesigma. Agricultural chemicals from maleic anhydride include pesticides, herbicides and growth regulators.
No other adverse effects attributable to exposure to maleic anhydride were noted at any treatment level. Since acetic anhydride is a relatively nonvolatile liquid, direct venting of the vapor to the atmosphere from a hole in a ruptured vessel does not consitiute a significant hazard downwind. Maleic anhydride msds 800408 milliporesigma emd millipore. Licocene pe ma 4221 fine grain is a maleic anhydride grafted, metallocene catalyzed polyethylene wax which is a highly efficient lubricant and dispersing aid for engineering plastics, especially for reinforced polyamide and polyester without an influence on color. Its major end use is as feedstock in the production of. Show this safety data sheet to the doctor in attendance. Unlock content over 79,000 lessons in all major subjects. Dehydration of maleic acid to form maleic anhydride. Application maleic anhydride may be used in the synthesis of unsaturated polyester resins and as a reactant in synthesizing important products such as agricultural chemicals, lubricant. When entering a maleic anhydride in the insulating material of the apparatus, there is.
In the dehydration of maleic acid to form maleic anhydride, comprising a first stage of concentrating an aqueous solution of maleic acid to 8595% by maleic acid, and a second stage of dehydrating the concentrated maleic acid into maleic anhydride, in at least one of the stages, a falling film tubular evaporator is employed. It was for work in 1928 on the reaction between maleic anhydride and 1,4butadiene that diels and alder were awarded the nobel prize in 1950. Only vapor released from a liquid pool spilled on a ground or water surfaces is. Maleic anhydride appears as colorless crystalline needles, flakes, pellets, rods, briquettes, lumps or a fused mass. Consumer exposure to maleic anhydride is uncommon, and worker exposure is controlled by protective equipment and ventilation. Maleic anhydride released into water will hydrolyze rapidly halflife 0. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Bioconcentration of maleic anhydride in aquatic organisms is unlikely due its rapid hydrolysissrc. Maleic anhydride may cause a skin allergy and an asthmalike allergy. First aid measures description of firstaid measures general advice. Sds of maleic anhydride, safety data sheets, cas 108316.
Maleic anhydride 95% may contain up to 5% maleic acid synonym. All structured data from the file and property namespaces is available under the creative commons cc0 license. Material safety data sheet west liberty university. Home maleic anhydride grafted products page contact optimized grafts optimized grafts msds. Name of substance maleic anhydride identifiers cas no 108316 molecular formula c4h2o3 molar mass 98. Occupational exposure limits, if available, are listed in section 8. Ingestion of maleic anydride is toxic and may cause digestive tract burns. Advanced industrial intermediates molecular formula. Dispose of contentscontainer to industrial combustion plant. Maleic anhydride rapidly forms maleic acid when in contact with water. Production of maleic anhydride biomedical engineering. Maleic anhydride test description specification unit test limits of measure method min. Appearance molten briquettes colour 20 apha astm336674 purity 99. Maleic anhydride is a classic substrate for dielsalder reactions.
Longterm health effects prolonged vapor contact to maleic anhydride may cause conjunctivitis and photophobia sensitivity of the eye to light. Maleic anhydride is used in the production of unsaturated polyester resin as well as in the manufacture of coatings, pharmaceutics, agricultural products, surfactants, and as an additive of plastics. Substance any concentration shown as a range is to protect confidentiality or is due to batch variation. Higher exposures may cause a buildup of fluid in the lungs pulmonary edema, a medical emergency. In addition, maleic anhydride hydrolyzes rapidly in water forming maleic acid with hydrolysis halflives of 3.
538 412 1569 1145 591 629 1214 379 1013 1176 334 715 385 1413 925 1346 1293 744 1181 291 376 1021 1237 415 42 34 641 218 1110 412 283 473 567